Immunoregulation by iNKT Cells

[Immunoregulation by iNKT cells].

NKT cells are defined as cells co-expressing of the natural killer receptors such as NK1.1 or NKR-P1A (CD161) and a T cell receptor (TCR). Although NK1.1(+) TCR(+) lymphocytes are heterogeneous, we focus on two distinct T cell subsets express invariant T cell receptor alpha chains, Valpha14-Jalpha18(Valpha14i) and Valpha19-Jalpha33(Valpha19i). Valpha14i NKT cells (Valpha24i NKT cells for human)...

Mediation of Immunoregulation by Dendritic Cells

GVHD protection? ThiNK iNKT cells.

In this issue of Blood, Rubio et al report that posttransplant invariant NKT (iNKT) cell recovery is inversely correlated with the risk of developing GVHD after stem cell transplantation.1 A llogeneic hematopoietic stem cell transplantation (HSCT) remains the best curative therapy for many patients with hematologic malignancies and/or marrow failure states. While significant advances in transpl...

Mesenchymal stem cells in immunoregulation.

Mesenchymal stem cells are present within the bone marrow cavity and serve as a reservoir for the continuous renewal of various mesenchymal tissues. Recent studies suggest that mesenchymal stem cells modulate immune reactions in vitro and escape from immune surveillance in vivo. We provide herein a discussion of issues including the current research progress on the in vitro interactions of mese...

Immunoregulation by Mesenchymal Stem Cells: Biological Aspects and Clinical Applications

Mesenchymal stem cells (MSCs) are multipotent cells capable of differentiation into mesenchymal lineages and that can be isolated from various tissues and easily cultivated in vitro. Currently, MSCs are of considerable interest because of the biological characteristics that confer high potential applicability in the clinical treatment of many diseases. Specifically, because of their high immuno...